UFC 322 Odds and Preview

One of the best Sambo wrestling experts on the planet defends his UFC title on Saturday when Islam Makhachev puts his stripe on the line versus tough Jack Della Maddalena. Makhachev is 27-1 and a massive favorite to hold onto his belt. Will Della Maddalena prove his doubters wrong? Before Makhachev and Della Maddalena get it on, the Women’s Flyweight Title is on the line when champions Valentina Schevchenko battles Zhang Weili. Check out UFC odds, analysis, and picks for this Saturday’s leading card at UFC 322.

UFC 322 Event Info

Can't leave your couch for these two fights!

Jack Della Maddalena vs @MAKHACHEVMMA
@BulletValentina vs Zhang Weili

[ B2YB: @DoorDash | #VeChain #UFC322 ] pic.twitter.com/1wrbiyGpHG

— UFC (@ufc) November 13, 2025

• When: Saturday, November 15th, 2025. 10pm EST
• Where: Madison Square Garden, New York City, NY
• TV: PPV
• Live Stream: UFC Fight Pass

UFC 322 Main Card Odds

UFC 322 Main Card Preview

Beneil Dariush vs. Benoit Saint Denis

The moneylines in this one suggest a rousing fight. Saint Denis started as the -210 favorite, but money has shifted to Dariush, pushing the dog to +160 and the favorite to -190.

The trend is in Dariush’s favor. When Beneil is on, he can for sure beat Saint Denis. So it’s a question of whether or not Dariush comes up with his A game. Going against the trend could be costly for us. So, back the value fighter.

UFC 322 Pick: Beneil Dariush

Leon Edwards vs. Carlos Prates

A few years ago, Edwards would have been the big-time chalk in this matchup. But 2025, heading into 2026, is much different than 2023.

Edwards has lost two straight, while Prates has won 4-of-5. Carlos won all four fights via KO/TKO. He’s on a nice knockout streak. Pairing a Prates win with a stoppage via KO or TKO will pay out big.

UFC 322 Pick: Carlos Prates

Sean Brady vs. Michael Morales

Brady is 18-1 while Morales is 18-0. Brady is also shorter than the underdog, which makes me question what it is in Morales’ past performances that make him the dog in this?

There it is. Michael is 13-0 with TKO/KO. He’s 1-0 via submission. Many believe that if Brady can get the fight to the mat, he has the edge. Ah, but can Brady get past Morales’ massive reach advantage? At +110, it’s worth backing “no” to that question.

UFC 322 Pick: Michael Morales

Valentina Schevchenko vs. Zhang Weili // UFC Women’s Flyweight Title

By fight night, Valentina could be the much bigger chalk. Shevchenko and Weili are two of the best mixed martial arts fighters at UFC, but the trend is evident here.

Weili started the -115 favorite over Schevchenko at -105. Since then, all the money has landed on Valentina to make the champ -125. However, Weili is in excellent form, and Shevchenko has fought Alex Grasso in three of her last five bouts. Taking a shot on the underdog is the play.

UFC 322 Pick: Zhang Weili

Jack Della Maddalena vs. Islam Makhachev // UFC Welterweight Title

The main event won’t be much of a fight. For sure, Della Maddalena will give it his all, but sometimes, it doesn’t matter how hard you fight. Your opponent outclasses you.

Makhachev will outclass Jack in this bout. Islam is too good. He’s also one of the most focused mixed martial artists out there, which means he won’t have a stormy night. The lone loss on Islam’s record came back in 2015. Since then, he’s won fifteen straight. Makhachev by submission is the call.

UFC 322 Pick: Islam Makhachev

Where to Bet on MMA with Crypto

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This is just one of the many sports betting guides that you can read here at Nitrobetting news. Stay tuned for more MMA previews and articles, and don’t forget to check out the latest MMA betting odds on our crypto sportsbook.