2025 NBA Week 4 Betting Predictions
As in every week during the NBA Regular Season, Week 4 promises massive matchups that could provide serious profit. The top games start on Monday, when the Spurs take on the Bulls at the United Center in Chicago, and conclude on Sunday, when the Mavericks host the Trail Blazers. Check out this week’s top NBA picks so that when NBA odds arrive, you’re ready to place your bets.
Top 2025 NBA Week 4 Games to Bet On
Four straight wins have the Cavs and Knicks climbing the ladder
— NBA (@NBA) November 10, 2025
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San Antonio Spurs vs. Chicago Bulls
- When: Monday, November 10th. 8:00 p.m. ET
- NBA Week 4 Odds: Spurs -175 / Bulls +145
The Spurs’ top rookie, Dylan Harper, is out, but that hasn’t slowed down the Spurs. Why? De’Aaron Fox is back, and he’s back with a vengeance, scoring 24 points in his 2025-2026 debut.
Fox and Wemby make for a potent combo. The Bulls are performing well this season, and this game takes place on Chicago’s court, but the Spurs appear to be a Western Conference contender. Go moneyline.
2025 NBA Week 4 Pick: San Antonio Spurs
Golden State Warriors vs. Oklahoma City Thunder
- When: Tuesday, November 11th. 8:00 p.m. ET
- NBA Week 4 Odds: TBA
The Warriors at Thunder promises to be a high-scoring game. Or does it? The Thunder are a fantastic defensive team, and Golden State, although possessing Hall of Fame players, starts with old Hall of Fame players.
The Warriors are already showing signs that the legs aren’t there this season, losing 4-of-5 heading into a November 9 matchup versus the Pacers. SGA and his mates roll.
2025 NBA Week 4 Pick: Oklahoma City Thunder
Denver Nuggets at LA Clippers
- When: Wednesday, November 12th. 10:30 p.m. ET
- NBA Week 4 Odds: TBA
Consider the over for sure. Both teams possess top scorers: Nikola Jokic and Jamal Murray for the Nuggets and Kawhi Leonard and James Harden for the Clippers.
Buckets shouldn’t be an issue. If you want to play a team ATS, take the points because the Nuggets are the better team overall.
2025 NBA Week 4 Pick: Over
Miami Heat vs. New York Knicks
- When: Friday, November 14th. 7:00 p.m. ET
- NBA Week 4 Odds: TBA
Why consider betting on this game? Let’s take a look at the Heat versus the Knicks, as Miami is 6-4 and leads by one contest in the Southeast.
Additionally, heading into the week, Miami has won four of its last five games straight up. The Knicks are 5-3 and on a 3-game winning streak as Monday approaches. But NYK should offer an underlay spread, which means the Heat will be the overlay.
2025 NBA Week 4 Pick: Miami Heat
Memphis Grizzlies vs. Cleveland Cavaliers
- When: Saturday, November 15th. 5:00 p.m. ET
- NBA Week 4 Odds: TBA
The Grizzlies at Cavaliers promises to be an intriguing matchup. Memphis finally got a win by leaning on Ja Morant, who had to sit out a game due to, well, his attitude last week. If Morant has gotten it together, he’s automatically one of the top two players on the court, no matter what team Memphis faces.
Cleveland is an NBA Finals contender. So, like Miami and New York, the home team should offer an underlay spread. Take advantage by grabbing the points.
2025 NBA Week 4 Pick: Memphis Grizzlies
Portland Trail Blazers vs. Dallas Mavericks
- When: Sunday, November 16th. 7:30 p.m. ET
- NBA Week 4 Odds: TBA
Will Anthony Davis and Derrick Lively play in this game? Maybe. The Mavericks’ top two frontcourt players are listed as out, but by the time this matchup happens, they could both be in line for big games.
If neither plays, take the points on the Blazers. Cooper isn’t yet good enough to carry Dallas; the kid is only 18, and Portland has some young talent led by center Donovan Clingan, along with a top veteran in Jrue Holiday. Right now, the Blazers are the play ATS.
2025 NBA Week 4 Pick: Portland Trail Blazers
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READ MORE: 2025 NBA Week 5 Betting Predictions
