2025 College Football Week 1 Betting Preview

The 2025 College Football Season is here! The season officially started this past Saturday. Thursday, though, is when the reason really kicks off. What plays should be on your radar heading into College Football Week 1? See below for the top picks along with college football odds to get the bankroll moving in a positive direction.

Top 2025 College Football Week 1 Games to Bet On

Boise State vs. South Florida

• When: Thursday, August 28th. 5:30 p.m. ET

• strong>College Football Week 1 Odds: Boise State -256 / South Florida +195

Boise State is going to be one of the better non-Power 4 Conference teams this season. But covering close to 7 points on the road versus an improved South Florida squad won’t be easy. Without Ashton Jeanty, the Raiders’ starting running back, the team will find it difficult to move the football as easily. So Flo can keep this close. They won’t win, but the Bulls should cover.

2025 College Football Week 1 Pick: South Florida +6

Texas vs. Ohio State

• When: Saturday, August 30th. 12:00 p.m. ET

• strong>College Football Week 1 Odds: Texas -103 / Ohio State -123

Texas kicks off as the top favorite to win the title, and they boast one of the few defenses that can stop Ohio State wide receiver Jeremiah Smith. But even if the Longhorns shut down Smith, Texas has a massive issue that’s likely to show up in Week 1 and badger the Horns all season.

The O-line isn’t close to what it was last season. Ohio State will exploit the problems along the O-Line, and this game happens in Columbus.

2025 College Football Week 1 Pick: Ohio State -1.5

Alabama vs. Florida State

• When: Saturday, August 30th. 3:30 p.m. ET

• strong>College Football Week 1 Odds: Alabama -625 / Florida State +400

Some college football experts are sleeping on the Bama Crimson Tide. Alabama should be as solid as they were in 2024. Better is more likely since it’s Kalen DeBoer’s second season.

The key for Alabama is the offensive line, which is massive, talented, and one of the best in the country. Expect a blowout statement victory from the Tide. FSU won’t keep up.

2025 College Football Week 1 Pick: Alabama -13.5

LSU vs. Clemson

• When: Saturday, August 30th. 7:30 p.m. ET

• strong>College Football Week 1 Odds: LSU +136 / Clemson -175

What a challenging game! Two of the best quarterbacks in the country, Garrett Nussmeier for LSU and Cade Klubnik for Clemson, duel in Death Valley.

The Tigers have the edge because the game is taking place on their home field. Also, LSU’s D isn’t close to Clemson’s. Dabo is bullish on his 2025 squad. We should be as well.

2025 College Football Week 1 Pick: Clemson -4

Notre Dame vs. Miami

• When: Sunday, August 31st. 7:30 p.m. ET

• strong>College Football Week 1 Odds: Notre Dame -137 / Miami +107

Notre Dame will have the running backs and offensive line to challenge Miami, but playing the Irish as a favorite on the road is a tough bet. Miami must replace Cam Ward. They did the same with Carson Beck, who could thrive in Mario Cristobal’s system.

Notre Dame can lose this straight up. The Canes cover if not win outright.

2025 College Football Week 1 Pick: Miami +2.5

TCU vs. North Carolina

• When: Monday, September 1st. 8:00 p.m. ET

• strong>College Football Week 1 Odds: Notre Dame -137 / Miami +107

Bill Belichick’s first game as head coach of the North Carolina Tar Heels could go either way. The truth is that Belichick is a damn good football coach. So it doesn’t matter whether he’s coaching pee wee, the NFL, or college. His players are going to go all in and play their hearts out.

TCU doesn’t have more talent than UNC. Since the game takes place at Chapel Hill, why not take the points?

2025 College Football Week 1 Pick: North Carolina +3.5

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READ MORE: 2025 College Football Week 2 Betting Preview