2025 NFL Week 7 Betting Preview
NFL Week 6 evened the playing field in a lot of ways after both the Bills and Eagles lost. Heading into NFL Week 7, parity exists in both leagues with no team boasting an undefeated record. Check out NFL odds, analysis, and picks for six of this week’s top games.
Top 2025 NFL Week 7 Games to Bet On
NFL WEEK 7 POWER RANKINGS
— The Sporting News (@sportingnews) October 14, 2025
Packers, Bucs, Colts rise; Eagles, Bills, Lions drop in shakeup up top
: https://t.co/IDCdGZEVdj pic.twitter.com/qFmvgSeFb5
LA Rams vs. Jacksonville Jaguars
- When: Sunday, October 19th. 9:30 a.m. ET
- NFL Week 7 Odds: Rams -149 / Jaguars +125
The Rams have enough to beat the Jaguars on the road, but Jacksonville will play with energy after losing a home game to Seattle in Week 6. The Jags’ offense never got going versus the Seahawks.
Also, and this is a big problem, Puka Nucua is day-to-day after suffering an ankle injury in the Rams’ last. If Puka isn’t one-hundred percent, the Jaguars’ defense could force Matthew Stafford into a couple of bad throws. At +2.5 and at home, the Jags are a solid pick.
2025 NFL 7 Pick: Jaguars
Las Vegas Raiders vs. Kansas City Chiefs
- When: Sunday, October 19th. 1:00 p.m. ET
- NFL Week 7 Odds: Raiders +500 / Chiefs -714
There are reasons to expect the Raiders to keep this one closer than the spread line. For starters, this is one of the top rivalries in the NFL. The Raiders and Chiefs are often closer than the spread.
Second, Vegas is finally doing what they should have been doing all season, which is to give Ashton Jeanty the football. Jeanty has had 20-plus carries in 2 of the last 3 Vegas games. The only time he carried the ball fewer than 20 times in the previous 3 was in the blowout loss to one of the best teams in the league, the Colts.
KC is flying high after beating Detroit, but the Raiders play hard and come off a decent win over the Titans. Vegas keeps a loss to 10 points or less.
2025 NFL 7 Pick: Raiders
Indianapolis Colts vs. LA Chargers
- When: Sunday, October 19th. 4:05 p.m. ET
- NFL Week 7 Odds: Colts +105 / Chargers -125
The one stat to consider when handicapping this game is that the Chargers’ defense gave up 128 yards and two rushing touchdowns to De’Von Achane in a too-close-for-comfort 29-27 win over the hapless Miami Dolphins.
Jonathan Taylor should dominate on the ground. Daniel Jones is more careful with the ball than Tua, who threw three picks, and the Colts’ D is playing great. Indianapolis is the play.
2025 NFL 7 Pick: Colts
Washington Commanders vs. Dallas Cowboys
- When: Sunday, October 19th. 4:25 p.m. ET
- NFL Week 7 Odds: Commanders +139 / Cowboys -169
When it comes to rivalry games, the home team often has the edge. Dallas shouldn’t be the underdog in this matchup. For sure, Washington’s offense can hang with the Boys’, but when it comes down to it, Dallas has the edge because they’re in front of their fans.
Also, Dak is playing great football. The Cowboys aren’t winning, but Prescott is on fire. He added another 2261 yards and 3 TD passes after completing over 73% in a loss to the Panthers.
2025 NFL 7 Pick: Cowboys
Atlanta Falcons vs. San Francisco 49ers
- When: Sunday, October 19th. 8:20 p.m. ET
- NFL Week 7 Odds: Falcons +111 / 49ers -133
In NFL Week 6, the injuries finally caught up to the San Francisco 49ers. Tampa Bay dusted SF 30-19. This Sunday, the Falcons have a shot to beat San Francisco because Fred Warner, the 49ers’ top defender, is out for the season.
Trying to tackle Bijan Robinson is going to be an issue. Also, Penix Jr. and Drake London have finally gotten going. So the Falcons can lean on a passing game. Raheem Morris’ defense will find a way to contain Mac Jones or a less than one-hundred percent Brock Purdy. The odds should be flipped.
2025 NFL 7 Pick: Falcons
Tampa Bay Buccaneers vs. Detroit Lions
- When: Monday, October 20th. 7:00 p.m. ET
- NFL Week 7 Odds: Buccaneers +200 / Lions -182
The Lions’ secondary is a mess. Aidan Hutchinson is playing great, but if AH doesn’t get pressure on the QB, quarterbacks like Baker Mayfield will carve up the secondary.
Mayfield is playing at an MVP level. After Week 6, Baker has thrown for 1,539 yards, 12 TDs, and a single interception. His completion percentage is 66.2%. The 5.5 points are too many to give to a Bucs squad that’s 5-1. Back Tampa for sure and consider a small play on the ML.
2025 NFL 7 Pick: Buccaneers
Where to Bet on NFL with Crypto
NFL odds are available all season round here at Nitrobetting. Create a Nitrobetting account now to win tons of cryptocurrency from the 2025-26 NFL season with our up-to-date NFL futures odds!
Check out our latest crypto betting guides for the NFL season. Stay tuned for more football previews and articles, and don’t forget to check out the latest NFL betting odds at our online crypto sportsbook.
*All stated odds are subject to change without prior notice.
READ MORE: 2025 NFL Week 8 Betting Preview
