Smartest 2025 NFL Betting Picks

The 2025 NFL Regular Season is on our doorstep. But there’s still time to place future bets that have the best chance of making a profit. What bets should be on your radar heading into the 2025 NFL Season? Keep reading for NFL betting odds, analysis, and free picks.

What Teams Are the Top 2025 NFL Betting Picks

Which teams have a realistic shot at the Super Bowl heading into Week 1? @RalphVacchiano gave his picks ⬇️https://t.co/X3CPfJiTzJ pic.twitter.com/3OnC9q3BsD

— FOX Sports: NFL (@NFLonFOX) August 25, 2025

Atlanta Falcons

• 2025 NFL Odds: Over 8.5 +110

Sweeping New Orleans and Carolina and splitting with the Buccaneers will lead to 5 wins. The ATL should have no trouble beating the Colts and Dolphins at home and the Jets and Cardinals on the road. The rest is gravy.

Kansas City Chiefs

• 2025 NFL Odds: Under 10.5 +135

The schedule is brutal. The AFC West is much better this season than last. Not only that, but the Chiefs must play the NFC East. Only the Giants are a sure win. So getting to 11 victories will be a challenge.

New Orleans Saints

• 2025 NFL Odds: Over 5.5 +140

The Saints should luck their way into at least six wins. The reason? The defense is better than many believe, while the offensive line is rock solid. So victories versus the Giants, a split with Tampa and the Panthers, victories over the Cardinals and Jets, and a lucky win against the Titans on the road could take the record to 6-11.

New England Patriots to Make the Playoffs

• 2025 NFL Odds: +164

Great NFL betting odds on a rising squad with a relatively easy schedule. The Patriots play the NFC South this season. Sweeping all four teams is possible. Even if it doesn’t happen, the Pats will challenge the Bills, and the yearly two-time beatdowns of the New York Jets should resume. So should the sweep of the Dolphins.

NFL Coach of the Year – Mike Vrabel

• 2025 NFL Odds: +750

If the Patriots make the playoffs after the 2024 season, Vrabel locks down coach of the year. The favorite is Chicago’s Ben Johnson. BJ has a much more challenging road because the NFC North is loaded. All four teams are capable of deep playoff runs. Only the Patriots and Bills are good enough to win the NFC East.

Denver Broncos to Win the 2025 AFC Championship

• 2025 NFL Odds: +750

Denver isn’t just a solid play to win the AFC. They’re an overlay at +2500 to win the Super Bowl. Beating Kansas City, the Raiders, and the Chargers in the AFC West won’t be easy, but this is Sean Payton’s third season, which means he’s going to crank up the play-calling.

Payton finally has his team. We should expect the Broncos, which looked awesome during preseason, to put the pedal to the floor in Week 1 and ride a wave all the way to the playoffs and possibly beyond.

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